Man's hand using ergonomic vertical mouse

The Best Vertical Mice of 2022

By Austin Meadows AccessoriesNo Comments

Humans aren’t designed to sit in front of a computer for 8+ hours a day. Nonetheless, most of us do just that, whether it’s for work, recreation, or both. Too often, this results in pain or discomfort in our hands, wrists, and backs. 

Upgrading the ergonomics of your computer setup can help. If you sit all day, consider a standing desk. If you use a laptop, consider using a laptop stand and a portable keyboard. And if you notice discomfort in your hand, wrist, arm or shoulder, consider using a vertical mouse. 

Vertical mice (mouses?!) allow your hand to rest in a more natural position. Often this is described as the “handshake” position, mimicking how you’d hold your hand when reaching out to greet someone. 

Many people find vertical mice to be far more comfortable than more traditional computer mouse designs. The best vertical mouse will leave your hand in a neutral position that can reduce strain on your wrist. That said, it certainly takes a while to get used to, so if you’ve just made the switch to a vertical mouse, give yourself a few weeks to adjust. 

Vertical mice are becoming more popular, which has led to the introduction of dozens of new designs and models. If you’re also looking to join the “vertical crew”, these are the best vertical ergonomic mouse options on the market today.

Best Vertical Mouse Overall: Logitech MX Vertical
  • Size: 5 x 4 x 4 inches
  • Connection: Wireless dongle, Bluetooth, wired
  • Battery Life: Up to 4 months
  • Compatibility: Windows, macOS

Best Value Vertical Mouse: Mojo Perfect Grip
  • Size: 5.4 x 2.9 x 2.7 inches
  • Connection: Wireless dongle, Bluetooth
  • Battery Life: Up to 6 months
  • Compatibility: Windows, macOS, Linux, mobile

Best Cheap Vertical Mouse: iClever Vertical Mouse
  • Size: 5.2 x 3.4 x 3.1 inches
  • Connection: Wireless dongle
  • Battery Life: Up to 3 months
  • Compatibility: Windows, macOS, Linux, ChromeOS

Best Vertical Gaming Mouse: ZLOT Vertical Gaming Mouse
  • Size: 4.3 x 2.8 x 3.0 inches
  • Connection: Wired
  • Battery Life: n/a
  • Compatibility: Windows, macOS (partially)

Best Left-Handed Vertical Mouse: Perixx Perimice-719L
  • Size: 4.1 x 2.6 x 2.3 inches
  • Connection: Wireless dongle (wired also available)
  • Battery Life: up to 2 months
  • Compatibility: Windows, macOS (partially)

Best Vertical Mouse for Large Hands: Evoluent VMDLW
  • Size: 4.6 x 3.6 x 3.3 inches
  • Connection: Wireless dongle (wired also available)
  • Battery Life: up to 4 months
  • Compatibility: Windows, macOS

Best Vertical Mouse Overall: Logitech MX Vertical

Logitech MX Vertical Wireless Mouse – Advanced Ergonomic Design Reduces Muscle Strain, Control and Move Content Between 3 Windows and Apple Computers (Bluetooth or USB), Rechargeable, Graphite

Logitech makes the best vertical mouse right now, and the competition isn’t even close. The company implemented advice from ergonomic experts when designing this model, and even went as far as to produce a research study comparing the ergonomic performance of their new model with that of a standard computer mouse.

The results noted a 10% reduction in muscle strain, although of course this should be taken with a grain of salt, since the study was run by Logitech itself. 

The result of all this research and development effort is the Logitech MX Vertical Wireless Mouse, one of very few models on the market to have actual ergonomic certifications. It’s designed so your wrist rests at a 57-degree angle, which Logitech claims is the most natural wrist position.

This claim could certainly be debated, but based on the comfort ratings and general customer feedback for this mouse, it’s believable. 

Ergonomics aside, the Logitech MX is just a good mouse. It’s precise, with a 4000 DPI rating, and can connect via a USB wireless dongle, Bluetooth, or USB C cable. It works well with both PC and Mac (in fact, it’s the best vertical mouse for Mac overall) and offers an impressive battery life of up to four months on a single charge. 

Another slick feature is Logitech FLOW. This enables cross-computer control, allowing you to use the mouse on multiple computers seamlessly—transferring files, copy/pasting text and more—on up to three computers. It’s a bit of a niche requirement, but if you use multiple computers for work, it can be a game changer. 

The only real downside is that it’s one of the more expensive options out there. While we personally think the Logitech MX is worth the cost, there are certainly cheaper options available.

  • Certified ergonomic design
  • Cross-computer control (actively use the mouse to control multiple computers seamlessly)
  • Connect wirelessly via USB dongle or Bluetooth, or a USB cable
  • Rechargeable battery with up to 4-month battery life
  • Works well with both PC and Mac
  • Expensive
Buy on Amazon

Best Value Vertical Mouse: Mojo Perfect Grip

MOJO Perfect Grip Dual Mode Silent Vertical Mouse - Bluetooth / Wireless Optical Ergonomic Mouse w/Adjustable Sensitivity and Quiet Buttons

Looking for a budget-friendly option? The Mojo Perfect Grip fits the bill. Although there are cheaper options like the iClever (below), the MOJO strikes a good balance between price, features, and comfort, and is our pick for the best value vertical wireless mouse. 

As with the Logitech model above, the Mojo can connect by either Bluetooth or wireless USB dongle. This improves the versatility of the device, and means that you don’t necessarily need to have a free USB slot in order to use it.

It has an adjustable DPI of up to 2400, and is compatible with most devices (Windows, Mac, Linux, and mobile). Another selling point is its sound, or lack thereof. The Mojo has very quiet clicks, which your coworkers will thank you for!

It’s also quite comfortable, with a neutral handshake position that could be described as even more vertical than the Logitech model. The Logitech MX has that 57 degree slant we mentioned, while the Mojo is almost entirely vertical.

It’s tough to know exactly which style you’d prefer without trying both, although it’s worth noting that the Logitech does tend to get better subjective comfort ratings and reviews overall.  

Battery life is good, at around six months depending on usage. Note that the Mojo uses a single AA rather than having an internal rechargeable battery. It comes with a battery, and given how long it lasts, we don’t see this as a problem, but others might.

The main downside of the Mojo is that it simply doesn’t have the build quality of a higher-end model. It’s a budget-friendly mouse, and its durability reflects that.

  • Bluetooth + 2.4GHz wireless connectivity
  • Quiet buttons
  • Neutral “handshake” grip
  • Compatible with Windows, Mac, Linux, and mobile
  • Adjustable DPI up to 2400
  • Durability could be better
Buy on Amazon

Best Cheap Vertical Mouse: iClever Vertical Mouse

Ergonomic Mouse, iClever WM101 Wireless Vertical Mouse 6 Buttons with Adjustable DPI 1000/1600/2000/2400 Comfortable 2.4G Optical Ergo Mouse for Laptop, Computer, Desktop, Windows, Mac OS, Gray Black

If you’re on a tight budget, or just want to try out the vertical mouse style without spending a lot of money, check out the iClever Vertical Mouse. This one has a somewhat different shape to the others on this list, but the feel is similar. 

Highlights of this mouse include very quiet clicks (almost no sound at all), an adjustable DPI up to 2400, cross-platform compatibility (Windows and Mac), and of course that budget-friendly price point. As with the Mojo above, the iClever uses a pair of AAA batteries, which last up to three months.

The downside is that some users have reported issues with scrolling consistency: essentially, the mouse scroll wheel works improperly at times. I own this mouse myself, and have used it frequently for the last 1.5 years. Ironically, a few days before writing this article, my iClever’s scroll wheel started malfunctioning, “jumping” up the page occasionally when I’m scrolling down. 

Given that it’s been working flawlessly for 18+ months, however, and the fact that it’s very affordable, I’m okay with the occasional scrolling glitch. For the price, the iClever is still a great mouse overall.

  • Very quiet clicks
  • USB dongle can be stored inside the mouse
  • Adjustable DPI up to 2400
  • Budget-friendly
  • Compatible with Windows and Mac
  • Issues with scroll wheel not uncommon
Buy on Amazon

Best Vertical Gaming Mouse: ZLOT Vertical Gaming Mouse

ZLOT Vertical Gaming Mouse,Wired RGB Ergonomic USB Joystick Programmable Laser Gaming Mice,6+1 Design,11 Buttons,1000 Hz Max Polling Rate,10000 Max DPI,Upgraded Version for Computer Gamers,Black

Most gamers aren’t overly concerned about ergonomics, but if you play as much GTA: V or Overwatch as I do, you probably should be! 

There aren’t a whole lot of vertical gaming mouse options on the market, and good ones are even less common. The best of them is the ZLOT Vertical Gaming Mouse, a unique (okay, strange) looking mouse, with a joystick-style rocker control on the top of the mouse that’s just in reach of your thumb.

For most games, you likely won’t use this rocker, but since you can reprogram it (along with all the other buttons) to perform whatever functions you like, it’s a useful option to have for more control-heavy games. The mouse has onboard memory to store your macros, so you can easily move it between machines.

The RGB lighting leaves you under no illusions that this mouse is aimed at gamers, and neither does the connectivity: in order to keep latency to a minimum, the ZLOT is a wired-only mouse that connects via a USB cable.

The ZLOT has a maximum DPI of 10,000, but unfortunately the lowest DPI is 2500, which will be too high for some. Lockups and other problems aren’t out of the ordinary with the bundled software, either, and it’s also Windows-only: the mouse may work on Mac, but you can’t change settings or reprogram buttons.

Even with the software issues, though, this an inexpensive way of getting good gaming-specific features in a vertical mouse form, and it works well enough (for Windows users, at least) to be our top pick in this underserved category.

  • 11 programmable buttons
  • On-board memory for button presets
  • Unique joystick “rocker”
  • Wired design for minimal latency
  • 10000 max DPI
  • Lowest DPI setting is 2500, which may be too high for some
  • Software is Windows-only, and doesn’t always work well
Buy on Amazon

Best Left-Handed Vertical Mouse: Perixx Perimice-719L

Perixx Perimice-719L, Left Handed Wireless Vertical Mouse, Portable Size for Laptops Computer, 3 Level DPI

Where are my left-handed folks at? 

Standard mice can often be used with either hand, as long as they are symmetrical and the buttons can be customized. With vertical mice… this is not the case.

The highly specialized design of a vertical mouse is hand-specific, so if you’re a lefty, you’ll definitely want to look into something like the Perixx Perimice-719L

This model comes in both wired and wireless configurations, and is fairly compact and portable. Clicks are quiet, and the mouse is certainly budget-friendly. While it’s designed for Windows, the 719L works fine on Mac as well, other than the forward and back buttons.

I’d describe this as a semi-vertical mouse, as it has a fairly substantial slant to it, allowing the hand to rest at roughly a 50-degree angle. This is comfortable for some, but is somewhere between a vertical mouse and a traditional mouse. If you want a fully vertical left-handed mouse, try the Evoluent VM4L instead.

  • Specifically designed for left-handed users
  • Available in wired and wireless models
  • Compact, portable design
  • Budget-friendly
  • Quiet clicks
  • Moderate hand angle may not be comfortable for some
  • Forward/back buttons don’t work properly on Mac browsers
Buy on Amazon

Best Vertical Mouse for Large Hands: Evoluent VMDLW

Evoluent VerticalMouse (The Original Brand Since 2002) VMDLW Large Right Hand Ergonomic Mouse with USB Wireless Receiver

If you have large hands, you likely know the struggle of finding a comfortable mouse. This can be particularly true with vertical mice, as they’re designed to curve with the shape of your hand to allow it to rest naturally.

If you’ve got larger hands, the Evoluent VMDLW is a great option. Ironically, Evoluent also makes the best vertical mouse for small hands, and also has a medium/standard size version as well. We’ll call that the Goldilocks model.

Evoluent was one of the first companies to make vertical mice, and remains a significant force in the industry today. The VMDLW is one of their largest models, with a comfortable, ergonomic design that’s best for those with hand lengths exceeding 7.5” (measured from the base of the hand/top of the wrist to the tip of the middle finger).

This model works well with both Mac and PC, and has programmable buttons that are also grooved for a more stable feel. 

On the downside, this mouse has a particularly glossy, smooth finish, which can cause sweaty/clammy hands, especially in warmer temperatures. It’s also a bit pricey, and while you’re paying for quality, there are certainly cheaper models out there.

  • Specifically designed for larger hands (small and medium versions also available)
  • Comfortable, ergonomic design
  • Compatible with PC and Mac
  • Grooved, programmable button
  • Glossy texture may cause hand sweating
  • Pricey
Buy on Amazon

Main image via Velimir Zeland/, product images via Amazon

About the Author
Austin Meadows

Austin Meadows

Austin is a digital nomad with a passion for exploring alternative lifestyles and testing the latest technological innovations. Rarely under the same roof for long, when he's not sampling wine and cheese in Bulgaria or downloading the latest travel app, you can find him running, gaming, or cooking up something delicious.

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